Drone weapon systems are in a rapid evolution phase today based on the global conflicts stage. Northrop Grumman (NG), in conjunction with Teledyne FLIR Systems has developed an Electronic Safe Arm and Fire (ESAF) fuze and warhead for Teledyne FLIR's Rogue 1 quadcopter platform. A miniature ESAF interfaces with several lethal effect payloads and integrates into the Rogue 1 gimbal assembly, providing unique directional control of the lethal effects. Teledyne FLIR has successfully demonstrated the operation of the Fuzing System in the Rogue 1 vehicle during multiple live-fire events. This paper will focus on the unique challenges associated with a quadcopter drone fuzing system design and culminating in successful live fire demonstrations tests.